Museo De La Salle is a lifestyle museum dedicated to the preservation of certain aspects and material culture of the 19th century Philippine ilustrado lifestyle. The Museo has been realized to encourage its own use in cross disciplinary learning and growth in an academic environment, and to provide a living space illustrating Philippine culture that is linked to its immediate community, and that reaches out to the outside.

Its collection comprises of antique family heirlooms such as furniture, decorative objects, fine and applied arts displayed in faithfully recreated rooms, donated by, or on long-term loan from collectors. Among the donors and lenders are Mr. Jose Ma. Ricardo A. Panlilio, scion of the Santos-Joven Panlilio family of Bacolor, Pampanga; Brother Andrew Gonzalez, FSC, of the Arnedo-Gonzales family of Sulipan Apalit, Pampanga; Ms. Marie Theresa Lammoglia-Virata, Ms. Victorina Vizcarra Amaliñgan, the D.M. Guevara Foundation Inc., Mr. Paulino and Ms Hetty Que, and former National Commission for Culture and the Arts Chairman Jaime C. Laya and the late international jeweler Fe Sarmiento - Panlilio.